Multidimensional Analysis of the Mother-to-child Transmission Risk Factors in Chronic Hepatitis B Virus Infection in Pregnant Women in Vietnam
V. 174 N. 3 (2023), Observational Study
V. 174 N. 3 (2023)

Multidimensional Analysis of the Mother-to-child Transmission Risk Factors in Chronic Hepatitis B Virus Infection in Pregnant Women in Vietnam : doi: 10.7417/CT.2023.2533

Observational Study
Pubblicato 2023-05-25
H.T. Ngoc Tram
Department of Obstetrics and Gynecology, Hanoi Medical University, Hanoi, Vietnam - Department of Obstetrics and Gynecology, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam
B.T. Thu Huong
Department of Biochemistry, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam - Department of Immunology and Molecular Genetics, Thai Nguyen National Hospital, Thai Nguyen, Vietnam
N. Duc Hinh
Department of Obstetrics and Gynecology, Hanoi Medical University, Hanoi, Vietnam
P.T. Thuy
Department of Biochemistry, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam
L.T. Lan Anh
Department of Medical Biology and Genetics, Hanoi Medical University, Hanoi, Vietnam
D.T. Kim Phuong
Department of Medical Biology and Genetics, Hanoi Medical University, Hanoi, Vietnam
H. Thu Lan
Department of Medical Biology and Genetics, Hanoi Medical University, Hanoi, Vietnam
H. Cam Tu
Center of Gene and Protein Research, Hanoi Medical University, Hanoi, Vietnam - Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany
N. Koerber
Institute of Virology, School of Medicine, Technical University of Munich, Helmholtz
T. Bauer
Institute of Virology, School of Medicine, Technical University of Munich, Helmholtz
H. Khanh Lam
Zentrum München, Munich, Germany; German Center for Infection Research (DZIF), Munich and Hamburg Partner sites, Germany
N. Manh Ha
Department of Internal Medicine, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam
N. Minh Duc
Department of Histology and Embryology, Hanoi Medical University, Hanoi, Vietnam
https://orcid.org/0000-0001-5411-1492
N. Thanh Hiep
Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam
U. Protzer
Institute of Virology, School of Medicine, Technical University of Munich, Helmholtz
N. Tien Dung
Department of Telecomunication, Hung Yen University of Technology and Education, Hung Yen, Vietnam
PDF

Parole chiave

chronic hepatitis B virus infection
liver
pregnant women
cord blood
peripheral blood mononuclear cells
cord blood mononuclear cells

Abstract

BACKGROUND: Hepatitis B virus (HBV) infection remains a major public health problem. The interaction between HBV and the host inflammatory response is an important factor contributing to liver damage and disease development. We compared the correlation between the subclinical index and PBMC (peripheral blood mononuclear cells) concentration in two groups of pregnant women in Vietnam (HBsAg positive), whose HBV DNA concentrations were different. METHODS: A multidimensional analysis was performed on data collected from 80 Vietnamese pregnant women and their babies (60/80 cord blood). RESULTS: When maternal viral load is higher than 5x107 copies/ml, the risk of being HBsAg positive in cord blood is 123% (RR=2.23 [1.48,3.36]); when viral load is lower than this baseline, the risk is decreased by 55% (RR=0.45 [0.30,0.67]) (p<0.001). In the high-viral-load group (HBV DNA ≥ 5x107 copies/ml), there was a strong correlation between CBMCs (cord blood mononuclear cells) and serum maternal hemoglobin concentration, maternal platelets, and maternal ALT. Their R values were -0.88, 0.82, and 0.84 with p=8.97x10-3, 2.41x10-2 and 1.75x10-1, respectively. CONCLUSIONS: We found a significant correlation shift of the subclinical index between the two groups, which may be important in diagnosing pregnant women with chronic hepatitis B virus infection.

 

PDF