Meta-analysis on the utility of radiotherapy for the treatment of Ocular Melanoma

doi: 10.7417/CT.2020.2195

  • D Messineo Department of Radiology, Oncology, and Anatomopathological, University Sapienza, Rome
  • G. Barile Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome
  • S. Morrone Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome
  • G. La Torre Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome
  • P. Turchetti National Institute for Health, Migration and Poverty (INMP/NIHMP), Rome
  • L. Accetta Department of Sense Organs, University of Rome “Sapienza”, Rome
  • E. Trovato Battagliola Department of Sense Organs, University of Rome “Sapienza”, Rome
  • E. Agostinelli International Polyamines Foundation-ONLUS, Rome, Italy
  • F. Pacella Department of Sense Organs, University of Rome “Sapienza”, Rome

Abstract

Introduction
Uveal melanoma is the most common intraocular tumor in the adult population. It can affect any part of the uveal tract: the iris, ciliary body, and choroid. Historically, enucleation has been the mainstay of treatment for primary melanoma. In the last decade, however, radiotherapy has acquired an increasingly important role and has now become our first-line modality. However, it is still widely debated what is the most effective radiotherapy technique for this tumor. Purpose to perform a literature review on the utility of radiotherapy for primary ocular melanoma and determine the most effective radiotherapy technique.


Materials and Methods
We included all systematic and narrative reviews on the topic, published between September 2007 and November 2017 on PubMed and SCOPUS. Two independent reviewers assessed the eligibility criteria for each article using the PRISMA checklist. The methodological quality of narrative and systematic reviews was evaluated with the INSA and AMSTAR checklists, respectively.


Results
Our study analyzed a total of 23 studies, including 18 narrative reviews and 5 systematic reviews. Radiotherapy with Brachytherapy, Proton Therapy, SRS/SRT with gamma knife and cyber knife, are the most common choices for the treatment of primary ocular melanoma. These techniques allow for excellent lesion spread control, eye, and vision conservation, and improve overall patients’ quality of life. Among the narrative reviews, the highest INSA score was 5/7, the lowest 2/7, the mean was 3.83/7 and median was 4/7. Among the systematic reviews, the highest AMSTAR score was 9/12, the lowest 4/12, the mean 5.6/7 and median 4/7.


Conclusion
The number of studies available on this topic is scarce. Among those published, the methodological quality is modest, as assessed with the INSA and AMSTAR checklists. As a result, we are not able to determine what the most effective radiotherapy technique is

Published
2019-12-17
How to Cite
MESSINEO, D et al. Meta-analysis on the utility of radiotherapy for the treatment of Ocular Melanoma. La Clinica Terapeutica, [S.l.], v. 1, n. 171, p. e89 - e98, dec. 2019. ISSN 1972-6007. Available at: <http://www.clinicaterapeutica.it/ojs/index.php/ClinicaTerapeutica/article/view/570>. Date accessed: 20 jan. 2020.
Section
Systematic review

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