Predictors and Trend of Ketoacidosis Hospitalization Rate in Type 2 Diabetes Mellitus Patients from 2006 to 2015 in Abruzzo Region, Italy

doi: 10.7417/CT.2020.2189

  • P. Di Giovanni Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, Chieti
  • F. Meo School of Hygiene and Preventive Medicine, “G. d’Annunzio” University of Chieti-Pescara, Chieti
  • F. Cedrone School of Hygiene and Preventive Medicine, “G. d’Annunzio” University of Chieti-Pescara, Chieti
  • M. D’Addezio School of Hygiene and Preventive Medicine, “G. d’Annunzio” University of Chieti-Pescara, Chieti
  • G. Di Martino School of Hygiene and Preventive Medicine, “G. d’Annunzio” University of Chieti-Pescara, Chieti
  • P. Scampoli chool of Hygiene and Preventive Medicine, “G. d’Annunzio” University of Chieti-Pescara, Chieti
  • A. Valente School of Hygiene and Preventive Medicine, “G. d’Annunzio” University of Chieti-Pescara, Chieti
  • F. Romano Department of Public Health and Infectious Disease, “La Sapienza” University of Rome, Rome
  • T. Staniscia Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti, Italy

Abstract

Aims
This study aimed to assess the trend of hospitalizations for DKA in adult patients with type 2 diabetes mellitus and its associated factors.


Design
A retrospective cross-sectional study was performed. Data were collected from hospital discharge records (HDRs) of patients (age ≥18) with either primary or secondary discharge diagnosis for DKA and type 2 diabetes from 2006 to 2015 in Abruzzo region. Age-adjusted hospitalization rates were computed by gender and standardized on the regional population in 2006. A logistic regression model was implemented using presence of DKA as dependent variable.


Results
We identified 160,366 HDRs with type 2 diabetes. Out of them, 1611 (1.00%) were due to DKA. The hospitalization rates for DKA increased both for male +115.9 and female +142.8%, from 2006 to 2015. The most significant predictors of DKA were age 18-44 (aOR=4.17), uncontrolled diabetes (aOR=1.79), trauma (aOR=1.38), any infection (aOR=1.68), liver disease (aOR=1.29), fluid and electrolyte disorders (aOR=2.09), psychosis (aOR=1.69).


Conclusions
Trends of DKA in adult patients with type 2 diabetes has been increasing in both male and female. Multimorbidity is an open challenge for public health, therefore better coordination is needed among different specialist consultants to reduce the occurrence of this preventable complication

Published
2019-12-17
How to Cite
DI GIOVANNI, P. et al. Predictors and Trend of Ketoacidosis Hospitalization Rate in Type 2 Diabetes Mellitus Patients from 2006 to 2015 in Abruzzo Region, Italy. La Clinica Terapeutica, [S.l.], v. 1, n. 171, p. e53 - e58, dec. 2019. ISSN 1972-6007. Available at: <http://www.clinicaterapeutica.it/ojs/index.php/ClinicaTerapeutica/article/view/558>. Date accessed: 20 jan. 2020.
Section
Research Article