Effects of sea salt rinses on subjects undergone to oral surgery: a single blinded randomized controlled trial

doi: 10.7417/CT.2020.2188

  • S. Cantore Department of Interdisciplinary Medicine , School of Medicine, University “Aldo Moro”, Bari - Sorriso e Benessere Ricerca e Clinica S.r.l., Bari
  • A. Ballini Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari “Aldo Moro”, Bari - Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, Bari
  • R. Saini Department of Interdisciplinary Medicine , School of Medicine, University “Aldo Moro”, Bar
  • V. Altini Sorriso e Benessere Ricerca e Clinica S.r.l., Bari
  • D. De Vito Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari “Aldo Moro”, Bari
  • F. Pettini Department of Interdisciplinary Medicine , School of Medicine, University “Aldo Moro”, Bari
  • G. Dipalma Department of Interdisciplinary Medicine , School of Medicine, University “Aldo Moro”, Bari
  • F. Inchingolo Department of Interdisciplinary Medicine , School of Medicine, University “Aldo Moro”, Bari

Abstract

Purpose
It has been customary to explain the dentally beneficial effects of xylitol and certain other natural compound as lysozyme and seas salt in terms of microbiological effects only. Several studies have tested the use of natural ingredients, alcohol and fluoride free, in mouthwashes. The purpose of this study was to evaluate a combined mouthwash formulation containing natural antibiofilm agents in oral care wound healing after routinely oral surgery (extraction) procedures.


Methods
Patients were assigned following a blinded randomized controlled trial and divided into two groups, an experimental group (I = 15) and a control (placebo) group (II = 15). Any infectious complications, wound healing, plaque accumulation in the stitches, and presence of trismus and inflammation were evaluated at ten and thirty days after extraction procedure. Pain and swelling were evaluated using the well-known visual analogue scale (VAS) scale throughout study period following extraction. The mean difference in Pre and Post values were compared among the groups. The change in pre–post score was analyzed using the paired t test.


Results
An appreciable wound healing was seen in the experimental group when compared to the control sites, with no reported adverse effects. Four weeks postoperative patient’s satisfaction level, to subjective and objective outcome measurements in documenting the result of a mouthwash treatment showed an interesting difference between groups.


Conclusions
Since combined mouthwash formulations, containing natural/bioactive substances, could provide a cheap, safe and acceptable alternative in oral care, further studies will also be required to study these effects and their mechanism of action in detail

Published
2019-12-17
How to Cite
CANTORE, S. et al. Effects of sea salt rinses on subjects undergone to oral surgery: a single blinded randomized controlled trial. La Clinica Terapeutica, [S.l.], v. 1, n. 171, p. e46 - e52, dec. 2019. ISSN 1972-6007. Available at: <http://www.clinicaterapeutica.it/ojs/index.php/ClinicaTerapeutica/article/view/557>. Date accessed: 20 jan. 2020.
Section
Research Article