Type 1 diabetes and MIG

doi: 10.7417/CT.2019.2177

  • D. Gonnella Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy


In Type 1 Diabetes (T1D), the monokine induced by interferon (IFN)-γ (MIG)/(C-X-C motif) receptor (CXCR)3 axis has a crucial role in β-cell destruction and in the autoimmune process of the disease, like many papers have reported. In fact, in T1D subjects the serum levels of the Type helper 1 chemokine MIG is increased, suggesting that this chemokine could be a predictive marker of T1D. Moreover, the pathophysiology of the disease course could be assessed by measuring MIG serum levels. A potential approach for T1D therapy could be the block of MIG expression at the beginning of the disease. Anyway, the chemokines-cytokines interactions in the T1D pathogenesis need to be further investigated

How to Cite
GONNELLA, D.. Type 1 diabetes and MIG. La Clinica Terapeutica, [S.l.], v. 170, n. 6, p. e465 - e471, nov. 2019. ISSN 1972-6007. Available at: <http://www.clinicaterapeutica.it/ojs/index.php/ClinicaTerapeutica/article/view/528>. Date accessed: 18 jan. 2020.