A systematic review and Meta-analysis on the association between Hand-Foot Syndrome (HFS) and Cancer Chemotherapy Efficacy

doi: 10.7417/CT.2019.2165

  • G. Falcone AOU Policlinico S. Orsola-Malpighi Bologna
  • C. Arrigoni Department of Public Health, Experimental and Forensic Medicine, Section of Hygiene, University of Pavia
  • F. Dellafiore Health Professions Research and Development Unit, IRCCS Policlinico San Donato, San Donato Milanese (Mi)
  • F. Gallucci Istituto Nazionale Tumori IRCCS Giovanni Pascale, Napoli
  • V. Milani Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese (Mi)
  • S. Boveri Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese (Mi)
  • D. Ausili Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
  • R. Caruso Health Professions Research and Development Unit, IRCCS Policlinico San Donato, San Donato Milanese (Mi)

Abstract

Hand-foot syndrome (HFS) is a common skin toxicity of traditional chemotherapies. Some studies showed that HFS has an association with progression-free survival (PFS) and the overall survival (OS). So far, there is not available any systematic literature reviews or meta-analysis aimed to assess the associations between HFS, PFS and OS. For this reason, this study aims to quantitatively summarize, critically review, and interpret the recent literature related to the associations between HFS and efficacy of chemotherapy in terms of PFS and OS. Queries shaped by PICOM framework, a systematic search of three electronic databases (PubMed, Scopus, and Science Direct) was carried out for the period between January 2010 and December 2017.
Quantitative data pooling was based on the calculation of Hazard Ratio (HR) with 95% Confidence Interval (95% CI) for the OS and PFS associated to the presence of HFS, through the data of original publications. Five papers were included in this systematic review for the quantitative data pooling. Patients with HFS showed improved PFS (HR = 0.532 [0.431-0.656]; p = 0.000) and improved OS (HR = 0.522 [0.427-0.638]; p = 0.000). HFS causes a reduction of compliance with oncology treatments. Healthcare providers should use this result as a trigger to foster patients’ coping and the one of their family caregivers, enhancing their adherence to cancer treatments

Published
2019-09-30
How to Cite
FALCONE, G. et al. A systematic review and Meta-analysis on the association between Hand-Foot Syndrome (HFS) and Cancer Chemotherapy Efficacy. La Clinica Terapeutica, [S.l.], v. 170, n. 5, p. e388 - e395, sep. 2019. ISSN 1972-6007. Available at: <http://www.clinicaterapeutica.it/ojs/index.php/ClinicaTerapeutica/article/view/492>. Date accessed: 22 oct. 2019.
Section
Systematic review