Cilostazol reduces dry eye symptoms and improve walking distance in patients with peripheral artery disease

doi: 10.7417/CT.2019.216

  • L.M. Chisari Department of Biomedical and Biotechnological Sciences, University of Catania
  • S. Malaguarnera Research Centre “The Great Senescence”, University of Catania
  • A. Grasso Department General Surgery and Medical Surgical Specialties University of Catania
  • M. Malaguarnera Research Centre “The Great Senescence”, University of Catania
  • G. Chisari Department of Biomedical and Biotechnological Sciences, University of Catania
  • A. M. Borzì Research Centre “The Great Senescence”, University of Catania
  • C. G. Chisari Department of Neurosciences - University of Catania

Abstract

Aim of the study
Cilostazol is a phosphodiesterase III inhibitor that has anti-inflammatory and immunomodulatory effects and can act with beneficial effect in Dry Eye Syndrome (DES). This clinical trial evaluates the effects of cilostazol on the tear film.


Materials and Methods
Following the run-in period, subjects were randomly into two groups: 40 subjects treated with cilostazol and 40 no-treated subjects.
The Walking Impairment Questionnaire (WIQ) has been administered to all patients.


Results
The data obtained from comparison of the two study groups A and B were, respectively, the following: Schirmer I: 10.2±0.2 Vs 13.8±0.4 (p< 0.001); Schirmer II: 3.8±0.1 Vs 4.6±0.2 (p<0.001); Break-up time (BUT) 4.2±0.3 Vs 6.5±0.2 (p<0.001) with disappearing of symptoms. The WIQ showed a significant difference in the walking distance (p<0.05) and calf pain severity (p<0.005) of treated patients.


In comparison with the placebo group, treated patients showed an improvement (p<0.03) in calf pain severity.


Conclusions
The administration of cilostazol was effective, in reducing DES and improve walking distance questionnaire

Published
2019-09-30
How to Cite
CHISARI, L.M. et al. Cilostazol reduces dry eye symptoms and improve walking distance in patients with peripheral artery disease. La Clinica Terapeutica, [S.l.], v. 170, n. 5, p. e357 - e363, sep. 2019. ISSN 1972-6007. Available at: <http://www.clinicaterapeutica.it/ojs/index.php/ClinicaTerapeutica/article/view/487>. Date accessed: 22 oct. 2019.