Mig chemokine in primary biliary cirrhosis

doi: 10.7417/CT.2019.2135

  • V. Mazzi Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

Abstract

Different studies investigated about the role of T-helper 1 cytokines and chemokines in primary biliary cirrhosis (PBC). Animal models with autoimmune cholangitis have been used to investigate the involvement of (C-X-C motif) receptor (CXCR)3 and its ligand (C-X-C motif) ligand (CXCL)9/monokine induced by interferon (IFN)-γ (MIG) in the pathogenesis of PBC, suggesting a contribution of MIG in the development of PBC. In patients with PBC, in particular at the level of the portal areas of diseased livers, MIG expression and CXCR3+ cells have been found. MIG is positively associated with the severity of liver fibrosis. In PBC, circulating MIG levels and CXCR3+ cells are related with the progression of the disease; in fact, their expression increases significantly in PBC patients with respect to controls. Furthermore, it has been shown a significant reduction of these chemokines in the serum of PBC patients after treatment with ursodeoxycholic acid

Published
2019-06-06
How to Cite
MAZZI, V.. Mig chemokine in primary biliary cirrhosis. La Clinica Terapeutica, [S.l.], v. 170, n. 3, p. e211 - e215, june 2019. ISSN 1972-6007. Available at: <http://www.clinicaterapeutica.it/ojs/index.php/ClinicaTerapeutica/article/view/425>. Date accessed: 18 june 2019.