Conservative surgical treatment in rectal cancer after complete pathological response to neoadjuvant treatment. Prospective observational study

doi: 10.7417/CT.2019.2133

  • V. Romeo UOC Chirurgia Generale ad Indirizzo Oncologico Azienda ospedaliera San Giovanni-Addolorata Rome
  • S.M. Tierno UOC Chirurgia Generale Ospedale M.G. Vannini Rome
  • V. Bellini UOC Oncologia Medica Azienda ospedaliera San Giovanni-Addolorata
  • A.D. Andrulli UOC Radioterapia Azienda ospedaliera San Giovanni-Addolorata
  • U. De Paula UOC Radioterapia Azienda ospedaliera San Giovanni-Addolorata
  • F. Stipa UOC Chirurgia Generale Ospedale M.G. Vannini Rome
  • D. Campagna UOC Anatomia Patologica Azienda ospedaliera San Giovanni-Addolorata Rome, Italy
  • C.E. Vitelli UOC Chirurgia Generale Ospedale M.G. Vannini Rome

Abstract

In 2012 we started a prospective observational study at  San Giovanni Addolorata Hospital in Rome for patients with rectal cancer with complete response to neoadjuvant therapy (nCRT). In our, IRB approved protocol, patients  are evaluated at time 0 by physical, endoscopic, pathological and radiological examinations.  6 weeks after completion of nCRT they are re-evaluated. In case of persistence or progression of disease patients undergo surgery with Total Mesorectal Excision. In case of complete or major clinical response they are re-evaluated at 12 weeks and subjected to transanal surgical excision to confirm complete pathological response (pCR).  If tumor is found in the transanal excision specimen the patient is operated upon whereas patients with pCR are followed up at 3 months interval

Published
2019-06-06
How to Cite
ROMEO, V. et al. Conservative surgical treatment in rectal cancer after complete pathological response to neoadjuvant treatment. Prospective observational study. La Clinica Terapeutica, [S.l.], v. 170, n. 3, p. e199 - e205, june 2019. ISSN 1972-6007. Available at: <http://www.clinicaterapeutica.it/ojs/index.php/ClinicaTerapeutica/article/view/423>. Date accessed: 22 oct. 2019.
Section
Research Article