Treatment of Peristomal granulomatosis with a Neem and Red Hypericum Oil application: Case studies

doi: 10.7417/CT.2019.2115

  • A. Del Missier Registered Nurse, Clinical Specialist in Ostomy Care, Latina
  • F. La Torre Professor in General Surgery, Director U.O.C. Trauma and Emergency Surgery “Sapienza Università di Roma” - Rome
  • E. Toma Registered Nurse, Clinical Specialist in Wound Care, Clinical Specialist in Ostomy Care, Independent Tissue Viability Consultant, Rome, Italy


Peristomal granulomatosis is a chronic inflammatory disease of uncertain aetiology, and a high recurrence rate. It frequently occurs in patients with  enterostomy and urostomy. The most frequent type affects the mucocutaneous junction, causing bleeding and painful nodular lesions, which complicate  management of the ostomy pouching system. Currently, only invasive treatments are available, consisting in cauterisation or surgical removal of the granuloma. Our objective was to evaluate efficacy of a topic mixture oil, composed by a 1:1 of extracts of Neem and Red Hypericum; amongst its many therapeutical properties, it is proven to inhibit  the  over-granulation process.

Two clinical cases presenting typical peristomal granulomatosis were selected. On first access after recruitment, the patients underwent an accurate nursing anamnesis, a global assessment was carried out according to the Toven Method and an assessment of peristomal sore skin according to SACS 2.0. Granulomatosis wounds were treated with the oil mixture, applied on a hydrofiber pad, secured over the wound site by means of a transparent film. This allowed the release of active ingredients while ensuring the pouching system secure adhesion. The chosen protocol consisted in 2 dressing changes per week, while monitoring the granulomatosis wound evolution by means of a TOR Form validated data form and documenting progress by taking photographs.

Initially a regression of the inflammatory process was observed, with significant decrease of bleeding and pain. Gradually, the proliferating lesions reduced in size (both width and extent), and eventually healed completely. The product was very well tolerated, even when in contact with the stoma mucous membrane.  No recurrence signs were observed either at the follow up visit 15 days from end of treatment, and in clinical case N.2 equally  none were present two months after treatment.

Compared to conventional methods which are invasive, not resolving, and not tolerated by patients,  the product  was demonstrated to be an innovative therapeutical solution, easy to apply, with no side effects and well-liked by patients. The excellent results obtained require further confirmation and validation through new studies on a statistically significant number of cases

How to Cite
DEL MISSIER, A.; LA TORRE, F.; TOMA, E.. Treatment of Peristomal granulomatosis with a Neem and Red Hypericum Oil application: Case studies. La Clinica Terapeutica, [S.l.], v. 170, n. 2, p. e86 - e92, apr. 2019. ISSN 1972-6007. Available at: <>. Date accessed: 20 jan. 2020.