Interferon-γ-induced protein 10 in Lyme disease

doi: 10.7417/CT.2017.1997

  • P. Fallahi Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
  • G. Elia Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
  • A. Bonatti Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

Abstract

Lyme disease is an infectious disease caused by bacteria of the Borrelia type, that affects about 300,000 people a year in the USA and 65,000 people a year in Europe. Borrelia infection, and Lyme disease, following occupational exposure has been frequently reported in USA, Europe and Asia.
The manifestations of Lyme disease include erythema migrans (EM), arthritis, neuroborrelliosis (NB), and others. Cytokines and chemokines primarily orchestrate leukocyte recruitment to the areas of Borrelia infection, and they are critical mediators of immune and inflammatory responses, in particular of the induction of interferon (IFN)-γ and IFN-γ dependent chemokines. In EM high levels of T helper (Th) 1 cells chemoattranctants [monokine induced by IFN-γ (MIG), IFN-γ-induced protein 10 (IP- 10), and IFN-inducible T cell alpha chemoattractant (I-TAC)] have been shown. Synovial tissues and fluids of patients with Lyme Arthritis (LA) (overall with antibiotic-refractory LA) contained exceptionally high levels of Th1 chemoattractants and cytokines, particularly MIG and IFN-γ.
In NB concentrations of IP-10 and I-TAC in the cerebrospinal fluid (CSF) were significantly higher, suggesting that IP-10 and I-TAC create a chemokine gradient between the CSF and serum and recruite C-X-C chemokine receptor 3-expressing memory CD4+ T-cells into the CSF of these patients. A positive association between the disseminating capacity of B. burgdorferi and early type I IFN induction has also been shown.
These results suggest that IFN-γ dependent chemokines are important biomarkers to monitor the progression and diffusion of the disease in patients with Borrelia infection; further larger studies are needed

Published
2017-03-31
How to Cite
FALLAHI, P.; ELIA, G.; BONATTI, A.. Interferon-γ-induced protein 10 in Lyme disease. La Clinica Terapeutica, [S.l.], v. 168, n. 2, p. e146 - e150, mar. 2017. ISSN 1972-6007. Available at: <http://www.clinicaterapeutica.it/ojs/index.php/ClinicaTerapeutica/article/view/34>. Date accessed: 22 oct. 2019.