Therapeutic effect of RA223 in the management of breast cancer bone metastases

doi: 10.7417/CT.2019.2100

  • R.P. Costa Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo
  • V. Tripoli Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo
  • A. Princiotta Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo
  • M. Licari Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo
  • D. Piazza Clinical Risk Management and Quality Unit, A.O.U.P. “P. Giaccone”, Palermo
  • F. Verderame Department of Oncology, Villa Sofia Cervello Hospital, Palermo
  • A. Pinto Internal Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo, Italy
  • A. Princiotta Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo

Abstract

Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic metastases from prostate cancer. Phase 1 and 2 trials documented a clinical efficacy also in breast cancer patients with predominately bone disease, highlighting a reduction in alkaline phosphatase and other bone biomarkers. In our institution, a patient with breast cancer affected by osteolytic metastases was treated with off-label use of Ra223.


Our patient had a good treatment compliance and up to now she has not been revealed the presence of SSE or hematological complications. Our preliminary experience shows that Ra223 may play a critical role to bone metastates in patients with breast cancer

Published
2019-02-14
How to Cite
COSTA, R.P. et al. Therapeutic effect of RA223 in the management of breast cancer bone metastases. La Clinica Terapeutica, [S.l.], v. 1, n. 170, p. e1 - e3, feb. 2019. ISSN 1972-6007. Available at: <http://www.clinicaterapeutica.it/ojs/index.php/ClinicaTerapeutica/article/view/335>. Date accessed: 23 mar. 2019.