The Impact of Oxidative Stress on Pregnancy. The Neglected Role of Alcohol Misuse
V. 175 N. 1 (2024), Review
V. 175 N. 1 (2024)

The Impact of Oxidative Stress on Pregnancy. The Neglected Role of Alcohol Misuse: doi: 10.7417/CT.2024.5033

Review
Pubblicato 2024-02-18
A. D’Angelo
Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy
M. Peracchini
USL Toscana Centro, Ospedale S. Giovanni di Dio, Firenze, Italy
A. Agostini
Department of Gynecology and Obstetrics – ASL Viterbo, Viterbo, Italy
C. Di Matteo
ASL 02 Chieti Abruzzo, Italy
M. Fiore
Institute of Biochemistry and Cell Biology, IBBC-CNR, Rome, Italy
M. Ceccanti
SITAC, Società Italiana per il Trattamento dell’Alcolismo e le sue Complicanze, Rome, Italy
M. Vitali
ASUR Marche, AV4, Ancona, Italy
M. P. Messina
Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy
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Parole chiave

oxidative stress
pregnancy
placenta
preeclampsia
IUGR
gestational diabetes
miscarriage
FASD

Abstract

Oxygen is essential for human life. However, it could cause damaging effects on biological systems causing oxidative stress. Oxidative stress defined as “an alteration in the pro-oxidant–antioxidant balance in favor of the former that leads to potential damage” is characterized by the release of reactive oxygen species (ROS). Oxidative stress is now recognized to play a central role in the pathophysiology of many different disorders, including complications of pregnancy such as placental pathology, preeclampsia (PE), intrauterine growth restriction (IUGR), gestational diabetes, and miscarriage. This narrative review aims to summarize pieces of evidence about the role of oxidative stress in the pathophysiology of the main obstetric complications with particular interest in the neglected role of alcohol abuse.

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