The role of mesotherapy in the management of spinal pain. A randomized controlled study
V. 175 N. 4 (2023), Clinical trial
V. 175 N. 4 (2023)

The role of mesotherapy in the management of spinal pain. A randomized controlled study: doi: 10.7417/CT.2023.2447

Clinical trial
Pubblicato 2023-07-02
S. Brauneis
Department of Anesthesiology, Critical Care and Pain Medicine, La Sapienza University of Rome, Rome, Italy
F. Araimo
Department of Anesthesiology, Critical Care and Pain Medicine, La Sapienza University of Rome, Rome, Italy
M. Rossi
Section Of Anesthesia in Specialty Surgeries, Department of Emergency and Internal Medicin Policlinico Universitario Agostino Gemelli, Sacro Cuore Catholic University, Rome, Italy
D. Russo
San Marco Hospice and Palliative Care, Latina, Italy
M. Mammucari
via aurelia 784
E. Maggiori
Primary Care Unit ASL RM 1, Rome, Italy
https://orcid.org/0000-0002-8972-2100
R. di Marzo
Member of the Italian Society of Mesotherapy, Rome, Italy
R. Vellucci
Palliative Care and Pain Therapy Unit - Anesthesiology and Resuscitation Department of Careggi University Hospital, Florence, Italy
F. Gori
Section of Anesthesia, Intensive Care, and Pain Medicine, Santa Maria della Misericordia University Hospital, Perugia, Italy
B. Bifarini
Section of Anesthesia, Intensive Care, and Pain Medicine, Santa Maria della Misericordia University Hospital, Perugia, Italy
E. Chinè
Unit of Pain Therapy, Policlinic of Tor Vergata, Viale Oxford, 81, 00133, Rome, Italy
R. Carpenedo
Unit of Pain Therapy, Policlinic of Tor Vergata, Viale Oxford, 81, 00133, Rome, Italy
T. Paolucci
Department of Medical and Oral Sciences and Biotechnologies (DiSmob), Physical medicine and Rehabilitation unit, G. D’Annunzio University of Chieti-Pescara, Italy
C. Giorgio
Rehabilitation Unit, F. Pirinei Hospital, Altamura, BA, Italy
F. Ritarossi
Department of Anesthesiology, Critical Care and Pain Medicine, La Sapienza University of Rome, Rome, Italy
S. Natoli
Dept. of Clinical Science and Translational Medicine. University of Rome Tor Vergata, Italy
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Parole chiave

spinal pain
mesotherapy
mesodermal modulation
pain

Abstract

Background. Mesotherapy is a technique through which active ingredients are administered into the thickness of the skin in order to increase the local analgesic effect.

Methods. 141 patients with spinal pain not responding to systemic therapy with NSAIDs were randomized to receive one or more intracutaneous drugs on a weekly basis.

Results. All patients achieved a pain reduction of at least 50% compared to baseline, and all tolerated the therapy without having to resort to systemic drug dose increases.

Conclusions. The data from our study show that the active ingredients infiltrated into the skin induce a mesodermal modulation between the infiltrated liquid and the cutaneous nervous and cellular structures from which the typical drug-saving effect of mesotherapy arises. Although further studies are needed to establish how to integrate mesotherapy in various clinical settings, it appears to be a useful tool available to the practicing physician. This research is also useful in guiding future clinical research.

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