Short-Period Temporal Dispersion Repolarization Markers in Elderly Patients with Decompensated Heart Failure.
V. 173 N. 4 (2022), Research article
V. 173 N. 4 (2022)

Short-Period Temporal Dispersion Repolarization Markers in Elderly Patients with Decompensated Heart Failure. : doi: 10.7417/CT.2022.2446

Research article
Pubblicato 2022-07-20
G. Piccirillo
Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, “Sapienza" University of Rome, Rome, Italy
F. Moscucci
Policlinico Umberto I, DAI Medicina Interna e Specialità Mediche, Rome, Italy
M. Carnovale
Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy
A. Corrao
Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy
I. Di Diego
Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy
I. Lospinuso
Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy
C. Caltabiano
Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy
M. Mezzadri
Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy
P. Rossi
Cardiology Division, Arrhythmology Unit, S. Giovanni Calibita, Isola Tiberina, Rome, Italy
D. Magrì
Department of Clinical and Molecular Medicine, S. Andrea Hospital, “Sapienza” University of Rome, Rome, Italy
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Parole chiave

Aging
Chronic Heart Failure
Mortality
QT
Tpeak-Tend
QTVI
Temporal Dispersion of Repolarization Phase

Abstract

Objectives    Aging and chronic heart failure (CHF) are responsible for the temporal inhomogeneity  of electrocardiogram (ECG) repolarization phase. In the past, short period repolarization-dispersion parameters were used as makers of mortality risk in different heart diseases, yet. Aim of this work was to evaluate risk of mortality or worsening condition in CHF elderly subjects by mean of  these repolarization variables.   

Method:  5 minutes ECG recordings were collected to assess the mean and standard deviation (SD) of the following variables: QT end (QTe), QT peak (QTp) and T peak to T end (Te) in 117 decompensated CHF (age range: from 49 to 103 years). 30-day mortality and high levels of NT-pro BNP (<75 percentile) were considered markers of decompensated CHF.

Results: A total of 27 patients (23%) died during the 30-day follow-up (overall mortality rate 23%). Te mean (odd ratio (or): 1.04, 95% confidence limit (cl): 1.02-1.09, p<0.01), NT-pro BNP (or: 1.00, 95% cl: 1.00-1.00, p<0.01) and LVMI (or : 0.98, 95% cl: 0.96-0.10, p<0.05) were associated to risk of mortality at the multivariable logistic analysis. On the contrary, the same statistical analysis selected TeSD (or: 1.36, 95% cl: 1.16-1.59, p<0.001) and LVEF (or: 0.91, 95% cl: 0.87-0.95,  p<0.001) as marker of decompensated CHF.

­Conclusion: In decompensated  CHF elderly subjects, Te mean seem be associated to  mortality and TeSD could be considered a risk factor  for CHF worsening and complications.    These evidences could provide useful tools for telemonitoring CHF elderly patients, ameliorating treatments and outcomes.

 (ClinicalTrials.gov number, NCT04127162)

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