Comparative study between conventional and new methods in defining the cause of death from anaphylactic shock
V. 172 N. 4 (2021), Short report
V. 172 N. 4 (2021)

Comparative study between conventional and new methods in defining the cause of death from anaphylactic shock: doi: 10.7417/CT.2021.2342

Short report
Pubblicato 2021-07-11
A. Costantino
Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, Pisa, Italy
E. Mezzetti
A. De Matteis
Department of Human anatomy, Histology, Forensic medicine and Orthopedics, Sapienza University of Rome, Rome, Italy
G. Volonnino
Department of Human anatomy, Histology, Forensic medicine and Orthopedics, Sapienza University of Rome, Rome, Italy
S. De Simone
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
V. Fazio
Department of Human anatomy, Histology, Forensic medicine and Orthopedics, Sapienza University of Rome, Rome, Italy
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Parole chiave

Anaphylaxis
anaphylactic shock
forensic medicine
mast cell
tryptase
anti-CD117
LTE4
miRNA
immunohistochemistry

Abstract

Anaphylaxis is defined as a rapid systemic reaction that develops in individuals previously exposed to specific allergens. The new exposure causes systemic cellular degranulation, which in turn leads to cardiovascular and respiratory changes that are fatal if not treated immediately.
One of the main problems of this scenario in the forensic field is the determination of a correct post-mortem diagnosis. Traditional methods, such as histopathological examination of the respiratory tract and the use of specific antibodies used in immunohistochemistry, are sensitive but not always specific and therefore do not guarantee a high degree of probability in the diagnosis of anaphylaxis.
For this reason, a new and promising research frontier in this field of forensic pathology could be represented by the application of miRNAs as biomarkers, as has been done in other areas of medicine

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